Evidence Browser: Source: CastellinoEtAl2014

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Publication:Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats
Reference:

Castellino FJ, Chapman MP, Donahue DL, et al. Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats. J Trauma Acute Care Surg 2014;76:1169-76.

Abstract:None
Publication Type:Animal experimental study", "Human observational study
Low Risk of Bias:
  • Adjustment for confounding
  • Baseline characteristics of sample
  • Causative factors defined
  • Causative factors measured accurately
  • Eligibility criteria
  • Representative sample from a relevant population
High Risk of Bias:
  • Coagulopathy appropriately defined
  • Coagulopathy assessed on arrival to hospital
Unclear Risk of Bias:
  • All eligible patients included
Risk of Bias Score:6