Evidence Base for TIC BN Evidence-Base

Relation:	Tissue_Perfusion→ SBP
Evidence:	Increasing severity of shock (worsening tissue hypoperfusion) is associated with increasing heart rate (HR), worsening hypotension and worsening metabolic acidosis. [References] WilliamsEtAl2013 Physiological compensation to maintain adequate tissue perfusion and oxygen delivery results in measurable changes in heart rate. Once these compensatory mechanisms are exhausted a progressive decline in blood pressure can be measured. Multiple confounding factors may also affect these vital signs. [References] ACoST2008 BirkhahnEtAl2005 GulyEtAl2011 LittleEtAl1995 Traditional vital signs (HR and SBP) have limitations as indicators of blood loss. [References] BraselEtAl2007 LittleEtAl1995 WilliamsEtAl2013

TIC BN Evidence-Base